A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection

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	A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection
	Sun, Qing-lei1,2,3 ; Sun, Li 1,2
刊名	FISH & SHELLFISH IMMUNOLOGY
	2015-11-01
卷号	47 期号:1 页码:313-320
关键词	Peptidoglycan recognition protein Cynoglossus semilaevis Agglutination Phagocytosis Antibacterial effects
英文摘要	Peptidoglycan recognition proteins (PGRPs) are members of the innate immune system that interact with bacteria by binding to bacterial peptidoglycan. In this study, we examined the expression and function of a short type of PGRP, CsPGRP-SC2, from tongue sole (Cynoglossus semilaevis). CsPGRP-SC2 contains 164 amino acid residues and shares 54.5%-65.3% overall sequence identities with other teleost PGRPs. CsPGRP-SC2 possesses an amidase domain with a conserved zinc binding site. CsPGRP-SC2 expression occurred in multiple tissues and was upregulated by bacterial and viral infection. Purified recombinant C5PGRP-SC2 (rC5PGRP-SC2) was able to bind and agglutinate Gram-positive bacteria in a Zn2+-dependent manner. rCsPGRP-SC2 enhanced the uptake of the bound bacteria by host phagocytes and reduced bacterial dissemination and colonization in host tissues. These results indicate that CsPGRP-SC2 is an innate immune factor that participates in host defense against bacterial infection. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000365053300036
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/82325]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Sun, Qing-lei,Sun, Li. A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2015,47(1):313-320.
APA	Sun, Qing-lei,&Sun, Li.(2015).A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,47(1),313-320.
MLA	Sun, Qing-lei,et al."A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 47.1(2015):313-320.