Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics
	Jing, Lijia 5; Shi, Jiyun 2,3; Fan, Di 2; Li, Yaqian 4; Liu, Renfa 1; Dai, Zhifei 1; Wang, Fan 2,3; Tian, Jie4
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-10-07
卷号	7 期号:39 页码:22095-22105
关键词	cerasome indocyanine green multimodal imaging photothermal therapy nanotheranostics
英文摘要	This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanol-amine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG(2000)-DOTA), followed by chelating radioisotope of Lu-177. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile. Both fluorescence and nuclear imaging showed that such agent could selectively accumulate in tumor site after intravenous injection of the cerasome agent into Lewis lung carcinoma tumor bearing mice, resulting in efficient photothermal ablation of tumor through a one-time NIR laser irradiation at the best time window. The ability to track the uptake of cerasomes on a whole body basis could provide researchers with an excellent tool for developing cerasome-based drug delivery agents, especially the strategy of labeling cerasomes with theranostic radionuclide Lu-177, enabling the ability of the Lu-177-labeled cerasomes for radionuclide cancer therapy and even the combined therapy.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
关键词[WOS]	MESOPOROUS SILICA NANOPARTICLES ; TRIGGERED DRUG-RELEASE ; PHOTOTHERMAL THERAPY ; IN-VIVO ; CONTRAST AGENTS ; GOLD NANOCAGES ; FLUORESCENCE ; MICROCAPSULES ; NANOPROBES ; EFFICACY
收录类别	SCI
语种	英语
WOS记录号	WOS:000362628900058
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/10034]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China 2.Peking Univ, Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Interdisciplinary Lab, Beijing 100101, Peoples R China 4.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
推荐引用方式 GB/T 7714	Jing, Lijia,Shi, Jiyun,Fan, Di,et al. Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(39):22095-22105.
APA	Jing, Lijia.,Shi, Jiyun.,Fan, Di.,Li, Yaqian.,Liu, Renfa.,...&Tian, Jie.(2015).Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES,7(39),22095-22105.
MLA	Jing, Lijia,et al."Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES 7.39(2015):22095-22105.