Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy
	Liu, Renfa 1; Jing, Lijia 1,3; Peng, Dong 2; Li, Yong 3; Tian, Jie2 ; Dai, Zhifei 1
刊名	THERANOSTICS
	2015
卷号	5 期号:10 页码:1144-1153
关键词	Copper sulfide nanoparticles Nanotheranostic agent Photoacoustic imaging Magnatic resonance imaging Photothermal therapy
英文摘要	The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Medicine, Research & Experimental
研究领域[WOS]	Research & Experimental Medicine
关键词[WOS]	MRI CONTRAST AGENTS ; IN-VIVO ; SYNERGISTIC THERAPY ; THERANOSTIC AGENT ; CANCER-CELLS ; ABLATION ; PLATFORM ; PROBE
收录类别	SCI
语种	英语
WOS记录号	WOS:000359472700008
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/8914]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
推荐引用方式 GB/T 7714	Liu, Renfa,Jing, Lijia,Peng, Dong,et al. Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy[J]. THERANOSTICS,2015,5(10):1144-1153.
APA	Liu, Renfa,Jing, Lijia,Peng, Dong,Li, Yong,Tian, Jie,&Dai, Zhifei.(2015).Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.THERANOSTICS,5(10),1144-1153.
MLA	Liu, Renfa,et al."Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy".THERANOSTICS 5.10(2015):1144-1153.