Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography
	Tang S(汤胜)1,2 ; Guo Y(郭勇)1 ; Liang XJ(梁晓静)1 ; Wei, Falin 3; Yang, Limin 3; Liu SJ(刘淑娟)1 ; Liu X(刘霞)1 ; Jiang SX(蒋生祥)1
刊名	Analytical Methods
	2015
卷号	7 期号:11 页码:4750-4756
ISSN号	1759-9660
通讯作者	刘淑娟 ; 刘霞
英文摘要	A novel mixed-mode monolithic stationary phase based on bonding of 4,5-imidazoledicarboxy acid to the surface of an organic-silica hybrid monolith was prepared and characterized. Satisfactory characteristics in terms of mechanical stability, permeability and reproducibility of the resultant monolithic column were achieved. A typical per aqueous chromatographic behavior was observed in water-rich mobile phases. The resultant monolithic column was applied for the efficient resolution of various polar and hydrophilic compounds under per aqueous or reversed-phase chromatographic conditions, which successfully demonstrated its suitability for the analysis of these polar compounds in highly aqueous mobile phases. The highest column efficiency obtained for the amines was 149000 N m⁻¹. The experimental results showed that the mixed-mode mechanism of hydrophobic and ion-exchange interactions was involved in the separation under the given conditions. The successful applications suggested that the mixed-mode organic-silica hybrid monolithic column could offer a wide range of retention behaviors and flexible selectivities toward polar compounds, achieving various target separations.
学科主题	分析化学与药物化学
收录类别	SCI
资助信息	the National Natural Science Foundation of China (nos. 21475143;21175143;20905072);the National Science & Technology Major Project of China (nos. 2011ZX05010-003;2011ZX05011)
语种	英语
WOS记录号	WOS:000355557500043
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/18468]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
作者单位	1.Key Laboratory of Chemistry of Northwestern Plant Resources, CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, China 3.Key Laboratory of Oil & Gas Production, China National Petroleum Corporation (CNPC) and Research Institute of Petroleum Exploration and Development (RIPED), Beijing 100083, China
推荐引用方式 GB/T 7714	Tang S,Guo Y,Liang XJ,et al. Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography[J]. Analytical Methods,2015,7(11):4750-4756.
APA	Tang S.,Guo Y.,Liang XJ.,Wei, Falin.,Yang, Limin.,...&Jiang SX.(2015).Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography.Analytical Methods,7(11),4750-4756.
MLA	Tang S,et al."Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography".Analytical Methods 7.11(2015):4750-4756.