High Impedance Droplet-Solid Interface Lipid Bilayer Membranes | |
Wang, Xuejing1; Ma, Shenghua1; Su, Yingchun1; Zhang, Ying1; Bi, Hongmei1; Zhang, Lixue2; Han, Xiaojun1 | |
刊名 | ANALYTICAL CHEMISTRY |
2015-02-17 | |
卷号 | 87期号:4页码:2094-2099 |
英文摘要 | A droplet-solid interface lipid bilayer membrane (DSLM) with high impedance was developed through controlling the contact area between an aqueous droplet and electrode. The electrode size can be easily controlled from millimeter to micrometer level. The droplet-solid interface lipid bilayer membranes were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and fluorescence microscopy. The fluorescence recovery after photobleaching (FRAP) was applied to determine the diffusion coefficient of egg PC DSLM to be 2.58 mu m(2) s(-1). The DSLM resistance can reach up to 26.3 G Omega, which was then used to study the ion channel behavior of melittin. The resistivity of the bilayer membrane decreased linearly with the increase of melittin concentration in the membrane. The high impedance and fluidity of DSLM makes it an ideal model cell membrane system for ion channel study and high-throughput drug screening. |
WOS标题词 | Science & Technology ; Physical Sciences |
类目[WOS] | Chemistry, Analytical |
研究领域[WOS] | Chemistry |
关键词[WOS] | CHANNEL ACTIVITY ; PHOSPHOLIPID-BILAYERS ; ELECTRICAL-PROPERTIES ; POROUS ALUMINA ; MELITTIN ; NANOPORE ; SPECTROSCOPY ; PORES ; THIOLIPIDS ; ELECTRODES |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000349806200014 |
内容类型 | 期刊论文 |
源URL | [http://ir.qibebt.ac.cn/handle/337004/6094] |
专题 | 青岛生物能源与过程研究所_仿生能源与储能系统团队 |
作者单位 | 1.Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Sch Chem Engn & Technol, Harbin 150001, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao Key Lab Solar Energy Utilizat & Energy St, Qingdao 266101, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xuejing,Ma, Shenghua,Su, Yingchun,et al. High Impedance Droplet-Solid Interface Lipid Bilayer Membranes[J]. ANALYTICAL CHEMISTRY,2015,87(4):2094-2099. |
APA | Wang, Xuejing.,Ma, Shenghua.,Su, Yingchun.,Zhang, Ying.,Bi, Hongmei.,...&Han, Xiaojun.(2015).High Impedance Droplet-Solid Interface Lipid Bilayer Membranes.ANALYTICAL CHEMISTRY,87(4),2094-2099. |
MLA | Wang, Xuejing,et al."High Impedance Droplet-Solid Interface Lipid Bilayer Membranes".ANALYTICAL CHEMISTRY 87.4(2015):2094-2099. |
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