Saliva Microbiota Carry Caries-Specific Functional Gene Signatures

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	Saliva Microbiota Carry Caries-Specific Functional Gene Signatures
	Yang, Fang 1; Ning, Kang 2,3; Chang, Xingzhi 2,3; Yuan, Xiao 1; Tu, Qichao 4; Yuan, Tong 4; Deng, Ye 4; Hemme, Christopher L.4; Van Nostrand, Joy 4; Cui, Xinping 5
刊名	PLOS ONE
	2014-02-12
卷号	9 期号:2
英文摘要	Human saliva microbiota is phylogenetically divergent among host individuals yet their roles in health and disease are poorly appreciated. We employed a microbial functional gene microarray, HuMiChip 1.0, to reconstruct the global functional profiles of human saliva microbiota from ten healthy and ten caries-active adults. Saliva microbiota in the pilot population featured a vast diversity of functional genes. No significant distinction in gene number or diversity indices was observed between healthy and caries-active microbiota. However, co-presence network analysis of functional genes revealed that caries-active microbiota was more divergent in non-core genes than healthy microbiota, despite both groups exhibited a similar degree of conservation at their respective core genes. Furthermore, functional gene structure of saliva microbiota could potentially distinguish caries-active patients from healthy hosts. Microbial functions such as Diaminopimelate epimerase, Prephenate dehydrogenase, Pyruvate-formate lyase and N-acetylmuramoyl-L-alanine amidase were significantly linked to caries. Therefore, saliva microbiota carried disease-associated functional signatures, which could be potentially exploited for caries diagnosis.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	SEA OIL PLUME ; STREPTOCOCCUS-MUTANS ; CHILDHOOD CARIES ; DENTAL-CARIES ; WHOLE-SALIVA ; ASSOCIATION ; EXPERIENCE ; COMMUNITY ; CHILDREN ; DIVERSITY
收录类别	SCI
语种	英语
WOS记录号	WOS:000331262600001
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/6259]
专题	青岛生物能源与过程研究所_单细胞中心
作者单位	1.Qingdao Municipal Hosp, Oral Res Ctr, Qingdao, Shandong, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Biofuels, Shandong Key Lab Energy Genet, Qingdao, Shandong, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, BioEnergy Genome Ctr, Qingdao, Shandong, Peoples R China 4.Univ Oklahoma, Inst Environm Genom, Norman, OK 73019 USA 5.Univ Calif Riverside, Dept Stat, Riverside, CA 92521 USA
推荐引用方式 GB/T 7714	Yang, Fang,Ning, Kang,Chang, Xingzhi,et al. Saliva Microbiota Carry Caries-Specific Functional Gene Signatures[J]. PLOS ONE,2014,9(2).
APA	Yang, Fang.,Ning, Kang.,Chang, Xingzhi.,Yuan, Xiao.,Tu, Qichao.,...&Xu, Jian.(2014).Saliva Microbiota Carry Caries-Specific Functional Gene Signatures.PLOS ONE,9(2).
MLA	Yang, Fang,et al."Saliva Microbiota Carry Caries-Specific Functional Gene Signatures".PLOS ONE 9.2(2014).