Nannochloropsis Genomes Reveal Evolution of Microalgal Oleaginous Traits | |
Wang, Dongmei1,2; Ning, Kang1,2; Li, Jing1,2; Hu, Jianqiang1,2; Han, Danxiang3; Wang, Hui4; Zeng, Xiaowei1,2; Jing, Xiaoyan1,2; Zhou, Qian1,2; Su, Xiaoquan1,2 | |
刊名 | PLOS GENETICS |
2014 | |
卷号 | 10期号:1页码:1 |
英文摘要 | Oleaginous microalgae are promising feedstock for biofuels, yet the genetic diversity, origin and evolution of oleaginous traits remain largely unknown. Here we present a detailed phylogenomic analysis of five oleaginous Nannochloropsis species (a total of six strains) and one time-series transcriptome dataset for triacylglycerol (TAG) synthesis on one representative strain. Despite small genome sizes, high coding potential and relative paucity of mobile elements, the genomes feature small cores of ca. 2,700 protein-coding genes and a large pan-genome of >38,000 genes. The six genomes share key oleaginous traits, such as the enrichment of selected lipid biosynthesis genes and certain glycoside hydrolase genes that potentially shift carbon flux from chrysolaminaran to TAG synthesis. The eleven type II diacylglycerol acyltransferase genes (DGAT-2) in every strain, each expressed during TAG synthesis, likely originated from three ancient genomes, including the secondary endosymbiosis host and the engulfed green and red algae. Horizontal gene transfers were inferred in most lipid synthesis nodes with expanded gene doses and many glycoside hydrolase genes. Thus multiple genome pooling and horizontal genetic exchange, together with selective inheritance of lipid synthesis genes and species-specific gene loss, have led to the enormous genetic apparatus for oleaginousness and the wide genomic divergence among present-day Nannochloropsis. These findings have important implications in the screening and genetic engineering of microalgae for biofuels. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Genetics & Heredity |
研究领域[WOS] | Genetics & Heredity |
关键词[WOS] | GENE AMPLIFICATION ; BACTERIA ; SEQUENCE ; PROTEIN ; ADAPTATION ; EXPRESSION ; EUKARYOTE ; BIOFUELS ; YEAST ; RATES |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000336525000053 |
内容类型 | 期刊论文 |
源URL | [http://ir.qibebt.ac.cn/handle/337004/6109] |
专题 | 青岛生物能源与过程研究所_单细胞中心 |
作者单位 | 1.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, CAS Key Lab Biofuels, Shandong Key Lab Energy Genet, Qingdao, Shandong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, BioEnergy Genome Ctr, Qingdao, Shandong, Peoples R China 3.Arizona State Univ, Coll Technol & Innovat, Lab Algae Res & Biotechnol, Mesa, AZ USA 4.Univ Maryland, Ctr Environm Sci, Inst Marine & Environm Technol, Baltimore, MD 21201 USA 5.Chinese Acad Sci, Inst Hydrobiol, Ctr Microalgal Biotechnol & Biofuels, Wuhan, Hubei, Peoples R China 6.Univ Maryland Baltimore Cty, Inst Marine Environm Technol, Baltimore, MD 21228 USA 7.Univ Maryland Baltimore Cty, Dept Marine Biotechnol, Baltimore, MD 21228 USA |
推荐引用方式 GB/T 7714 | Wang, Dongmei,Ning, Kang,Li, Jing,et al. Nannochloropsis Genomes Reveal Evolution of Microalgal Oleaginous Traits[J]. PLOS GENETICS,2014,10(1):1. |
APA | Wang, Dongmei.,Ning, Kang.,Li, Jing.,Hu, Jianqiang.,Han, Danxiang.,...&Xu, Jian.(2014).Nannochloropsis Genomes Reveal Evolution of Microalgal Oleaginous Traits.PLOS GENETICS,10(1),1. |
MLA | Wang, Dongmei,et al."Nannochloropsis Genomes Reveal Evolution of Microalgal Oleaginous Traits".PLOS GENETICS 10.1(2014):1. |
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