Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones
Nie, LF (Nie, Li-Fei)[ 1,2 ]; Wang, SS (Wang, Si-Si)[ 3 ]; Cao, JG (Cao, Jian-Guo)[ 3 ]; Liu, FZ (Liu, Fei-Ze)[ 1,2 ]; Xiamuxi, HBM (Xiamuxi, Hainimu)[ 1,2 ]; Aisa, HA (Aisa, Haji Akber)[ 1 ]; Huang, GZ (Huang, Guo-Zheng)[ 1,3 ]
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2020
卷号22期号:1页码:69-82
关键词Thieno[2 3-d]pyrimidinone evodiamine rutaecarpine hybrid cytotoxicity
ISSN号1028-6020
DOI10.1080/10286020.2018.1540599
英文摘要

Dozens of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones were synthesized in a straightforward method by condensation of substituted 2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-diones or N-methyl-2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-dione with 3,4-dihydro-beta-carbolines. In vitro cytotoxic assay discovered that compounds 9a, 10e, 11a, 11d, 11f, and 12a could induce antiproliferation against four different types of human cancer cells while compounds 10f and 12e were inactive. Notably, compound 11a displayed potent cell cytotoxicity for human non-small cell lung cancer cells A549, PC-9, human prostate cancer cells PC-3, and human breast cancer cell line MCF-7. Furthermore, compound 11a exhibited strong colony formation inhibition to A549 cells. These results unfold potential anticancer therapeutic applications of hybrids of thieno[2,3-d]pyrimidinones and quinazolinones.

WOS记录号WOS:000505656500009
内容类型期刊论文
源URL[http://ir.xjipc.cas.cn/handle/365002/7209]  
专题新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA (Aisa, Haji Akber)[ 1 ]
作者单位1.Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai 201418, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
推荐引用方式
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Nie, LF ,Wang, SS ,Cao, JG ,et al. Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2020,22(1):69-82.
APA Nie, LF .,Wang, SS .,Cao, JG .,Liu, FZ .,Xiamuxi, HBM .,...&Huang, GZ .(2020).Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,22(1),69-82.
MLA Nie, LF ,et al."Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 22.1(2020):69-82.
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