Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones | |
Nie, LF (Nie, Li-Fei)[ 1,2 ]; Wang, SS (Wang, Si-Si)[ 3 ]; Cao, JG (Cao, Jian-Guo)[ 3 ]; Liu, FZ (Liu, Fei-Ze)[ 1,2 ]; Xiamuxi, HBM (Xiamuxi, Hainimu)[ 1,2 ]; Aisa, HA (Aisa, Haji Akber)[ 1 ]; Huang, GZ (Huang, Guo-Zheng)[ 1,3 ] | |
刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH |
2020 | |
卷号 | 22期号:1页码:69-82 |
关键词 | Thieno[2 3-d]pyrimidinone evodiamine rutaecarpine hybrid cytotoxicity |
ISSN号 | 1028-6020 |
DOI | 10.1080/10286020.2018.1540599 |
英文摘要 | Dozens of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones were synthesized in a straightforward method by condensation of substituted 2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-diones or N-methyl-2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-dione with 3,4-dihydro-beta-carbolines. In vitro cytotoxic assay discovered that compounds 9a, 10e, 11a, 11d, 11f, and 12a could induce antiproliferation against four different types of human cancer cells while compounds 10f and 12e were inactive. Notably, compound 11a displayed potent cell cytotoxicity for human non-small cell lung cancer cells A549, PC-9, human prostate cancer cells PC-3, and human breast cancer cell line MCF-7. Furthermore, compound 11a exhibited strong colony formation inhibition to A549 cells. These results unfold potential anticancer therapeutic applications of hybrids of thieno[2,3-d]pyrimidinones and quinazolinones. |
WOS记录号 | WOS:000505656500009 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/7209] |
专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
通讯作者 | Aisa, HA (Aisa, Haji Akber)[ 1 ] |
作者单位 | 1.Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai 201418, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China |
推荐引用方式 GB/T 7714 | Nie, LF ,Wang, SS ,Cao, JG ,et al. Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2020,22(1):69-82. |
APA | Nie, LF .,Wang, SS .,Cao, JG .,Liu, FZ .,Xiamuxi, HBM .,...&Huang, GZ .(2020).Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,22(1),69-82. |
MLA | Nie, LF ,et al."Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 22.1(2020):69-82. |
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