Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy

doi:10.1002/anie.201912824

	Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy
	Huo, Minfeng; Wang, Liying; Zhang, Linlin; Wei, Chenyang; Chen, Yu; Shi, Jianlin
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2019-12-31
关键词	cyanobacteria oxygenation photodynamic therapy photosensitizers photosynthesis
ISSN号	1433-7851
DOI	10.1002/anie.201912824
文献子类	Article; Early Access
英文摘要	Sustained tumor oxygenation is of critical importance during type-II photodynamic therapy (PDT), which depends on the intratumoral oxygen level for the generation of reactive oxygen species. Herein, the modification of photosynthetic cyanobacteria with the photosensitizer chlorin e6 (ce6) to form ce6-integrated photosensitive cells, termed ceCyan, is reported. Upon 660 nm laser irradiation, sustained photosynthetic O-2 evolution by the cyanobacteria and the immediate generation of reactive singlet oxygen species (O-1(2)) by the integrated photosensitizer could be almost simultaneously achieved for tumor therapy using type-II PDT both in vitro and in vivo. This work contributes a conceptual while practical paradigm for biocompatible and effective PDT using hybrid microorganisms, displaying a bright future in clinical PDT by microbiotic nanomedicine.
WOS关键词	BACTERIA ; NANOPARTICLES ; CANCER
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27452]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Huo, Minfeng,Wang, Liying,Zhang, Linlin,et al. Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019.
APA	Huo, Minfeng,Wang, Liying,Zhang, Linlin,Wei, Chenyang,Chen, Yu,&Shi, Jianlin.(2019).Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Huo, Minfeng,et al."Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019).