Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy

doi:10.1038/s41467-019-09158-1

	Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
	Fan, Wenpei; Lu, Nan; Shen, Zheyu; Tang, Wei; Shen, Bo; Cui, Zhaowen; Shan, Lingling; Yang, Zhen; Wang, Zhantong; Jacobson, Orit
刊名	NATURE COMMUNICATIONS
	2019-03-18
卷号	10
ISSN号	2041-1723
DOI	10.1038/s41467-019-09158-1
文献子类	Article
英文摘要	The success of radiotherapy relies on tumor-specific delivery of radiosensitizers to attenuate hypoxia resistance. Here we report an ammonia-assisted hot water etching strategy for the generic synthesis of a library of small-sized (sub-50 nm) hollow mesoporous organosilica nanoparticles (HMONs) with mono, double, triple, and even quadruple framework hybridization of diverse organic moieties by changing only the introduced bissilylated organosilica precursors. The biodegradable thioether-hybridized HMONs are chosen for efficient co-delivery of tert-butyl hydroperoxide (TBHP) and iron pentacarbonyl (Fe(CO)(5)). Distinct from conventional RT, radiodynamic therapy (RDT) is developed by taking advantage of X-ray-activated peroxy bond cleavage within TBHP to generate center dot OH, which can further attack Fe (CO)(5) to release CO molecules for gas therapy. Detailed in vitro and in vivo studies reveal the X-ray-activated cascaded release of center dot OH and CO molecules from TBHP/Fe(CO)(5) co-loaded PEGylated HMONs without reliance on oxygen, which brings about remarkable destructive effects against both normoxic and hypoxic cancers.
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27269]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Fan, Wenpei,Lu, Nan,Shen, Zheyu,et al. Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy[J]. NATURE COMMUNICATIONS,2019,10.
APA	Fan, Wenpei.,Lu, Nan.,Shen, Zheyu.,Tang, Wei.,Shen, Bo.,...&Chen, Xiaoyuan.(2019).Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy.NATURE COMMUNICATIONS,10.
MLA	Fan, Wenpei,et al."Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy".NATURE COMMUNICATIONS 10(2019).