Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy

doi:10.1002/adfm.201903733

CORC > 化学研究所 > 中国科学院化学研究所

	Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy
	Li, Yawen; Liu, Zitong; Ma, Yufan; Chen, Yuzhi; Ma, Kun; Wang, Xuefei; Zhang, Deqing; Wang, Zhuo
刊名	ADVANCED FUNCTIONAL MATERIALS
	2019-09-01
卷号	29 期号:38
ISSN号	1616-301X
DOI	10.1002/adfm.201903733
英文摘要	Semiconducting polymer nanoparticles (SPNs) have potential in biological applications. While some SPNs have significant photothermal conversion efficiencies (PCEs) as photothermal and photoacoustic agents, other SPNs offer high fluorescence yields as photoluminescent agents. However, the energy balance distribution in SPNs inhibits their successful applications in photoluminescence/photoacoustic (PL/PA) dual-modality imaging. Additionally, the ultrastability of SPNs in vivo may cause damage to organisms. This work reports nanocomposite semiconducting polymer and tetraphenylethene nanoparticles (STNPs) constructed by semiconducting polymers (SPs) and tetraphenylethene aggregation-induced emission luminogens (TPE AIEgens). The SP SPC10 endows good photothermal conversion ability, and the AIEgen TPBM supports enhanced photoluminescence of the STNPs. The results show that the STNPs can act as PL/PA dual-modality imaging agents. The signal-to-noise (S/N) ratio in the PL modality reaches 8.7, and the imaging depth in the PA modality is 5.8 mm. The SPC10 in the STNPs can be decomposed under 90 mW cm(-2) white light irradiation in 6 h without any other additional agents. Furthermore, the STNPs are sufficient for the treatment of xenograft 4T1 tumor-bearing mice based on photothermal therapy. The nanocomposite STNPs achieve optimized dual-modality PL/PA imaging and the AIEgen-triggered in situ photodegradation of SPNs. These properties indicate the significant potential of STNPs in clinical diagnosis and noninvasive therapy.
语种	英语
WOS记录号	WOS:000478459800001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/82725]
专题	中国科学院化学研究所
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Yawen,Liu, Zitong,Ma, Yufan,et al. Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(38).
APA	Li, Yawen.,Liu, Zitong.,Ma, Yufan.,Chen, Yuzhi.,Ma, Kun.,...&Wang, Zhuo.(2019).Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy.ADVANCED FUNCTIONAL MATERIALS,29(38).
MLA	Li, Yawen,et al."Semiconducting Nanocomposite with AIEgen-Triggered Enhanced Photoluminescence and Photodegradation for Dual-Modality Tumor Imaging and Therapy".ADVANCED FUNCTIONAL MATERIALS 29.38(2019).