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Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule
Chen, Gui-Lin3,4; Fan, Min-Xia2,4; Wu, Jian-Lin1; Li, Na1; Guo, Ming-Quan3,4
刊名FOOD CHEMISTRY
2019-03-30
卷号277页码:706-712
关键词Antioxidant Anti-inflammatory Flavonoids Lotus plumule UF-LC/MS
ISSN号0308-8146
DOI10.1016/j.foodchem.2018.11.040
英文摘要The antioxidant and anti-inflammatory mechanisms of action of flavonoids in lotus plumule were systematically analyzed using radical scavenging assays and ELISA kits. By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS(+) free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE(2) and TNF-alpha) and pro-inflammatory cytokines (IL-1 beta and IL-6). Meanwhile, the bioactive components against inflammation targeting COX-2 were also revealed using ultrafiltration coupled to LC-MS (UF-LC/MS). In this way, 12 components showing specific binding to COX-2 were screened out and identified. The structure-activity relationships suggested that flavonoids O-glycosides displayed comparable binding affinities to COX-2 compared with flavonoids C-glycosides and could be considered as the main active components. This study will provide valuable information for the further exploration of lotus plumule as functional foods or in pharmaceutical industries in the near future.
资助项目Natural Science Foundation of China[81673580] ; Macau Science and Technology Development Fund[009/2017/A1] ; Major Project for Special Technology Innovation of Hubei Province[2017AHB054]
WOS研究方向Chemistry ; Food Science & Technology ; Nutrition & Dietetics
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000451430800087
内容类型期刊论文
源URL[http://202.127.146.157/handle/2RYDP1HH/3530]  
专题中国科学院武汉植物园
通讯作者Guo, Ming-Quan
作者单位1.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan, Hubei, Peoples R China
4.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714
Chen, Gui-Lin,Fan, Min-Xia,Wu, Jian-Lin,et al. Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule[J]. FOOD CHEMISTRY,2019,277:706-712.
APA Chen, Gui-Lin,Fan, Min-Xia,Wu, Jian-Lin,Li, Na,&Guo, Ming-Quan.(2019).Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule.FOOD CHEMISTRY,277,706-712.
MLA Chen, Gui-Lin,et al."Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule".FOOD CHEMISTRY 277(2019):706-712.
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