Ecological Effect of Arginine on Oral Microbiota
Zheng X, He J, Wang L, Zhou S, Peng X, Huang S, Zheng L, Cheng L, Hao Y, Li J, Xu J, Xu X, Zhou; Xuedong Zhou
SourceSci Rep
Keyword1450 Ppm Fluoride insoluble Calcium Compound light-induced Fluorescence dental-caries 1.5-percent Arginine streptococcus-mutans 8-percent Arginine alkali Production childhood Caries in-vitro
English AbstractDental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in the oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating microbial composition in an in vitro consortium. However, the effect of arginine on the oral microbiota has yet to be comprehensively delineated in either clinical cohort or in vitro biofilm models that better represent the microbial diversity of oral cavity. Here, by employing a clinical cohort and a saliva-derived biofilm model, we demonstrated that arginine treatment could favorably modulate the oral microbiota of caries-active individuals. Specifically, treatment with arginine-containing dentifrice normalized the oral microbiota of caries-active individuals similar to that of caries-free controls in terms of microbial structure, abundance of typical species, enzymatic activities of glycolysis and alkali-generation related enzymes and their corresponding transcripts. Moreover, we found that combinatory use of arginine with fluoride could better enrich alkali-generating Streptococcus sanguinis and suppress acidogenic/aciduric Streptococcus mutans, and thus significantly retard the demineralizing capability of saliva-derived oral biofilm. Hence, we propose that fluoride and arginine have a potential synergistic effect in maintaining an eco-friendly oral microbial equilibrium in favor of better caries management.
WOS Keyword1450 ppm fluoride insoluble calcium compound light-induced fluorescence dental-caries 1.5-percent arginine streptococcus-mutans 8-percent arginine alkali production childhood caries in-vitro
WOS IDWOS:000406889500035
Funding OrganizationThis work was supported by the National Natural Science Foundation of China (81371135 to JL, 81430011 to XZ), Brilliant Young Investigator Award of Sichuan University (2015SCU04A16 to XX), the State Key Laboratory of Oral Diseases (Sichuan University) Open Fund (SKLOD2016OF03), and Sichuan Province Science and Technology Innovation Team Program (2017TD0016).
Content Type期刊论文
Corresponding AuthorXuedong Zhou
Recommended Citation
GB/T 7714
Zheng X, He J, Wang L, Zhou S, Peng X, Huang S, Zheng L, Cheng L, Hao Y, Li J, Xu J, Xu X, Zhou,Xuedong Zhou. Ecological Effect of Arginine on Oral Microbiota[J]. Sci Rep,4295,7(7206):2045-2322.
APA Zheng X, He J, Wang L, Zhou S, Peng X, Huang S, Zheng L, Cheng L, Hao Y, Li J, Xu J, Xu X, Zhou,&Xuedong Zhou.(4295).Ecological Effect of Arginine on Oral Microbiota.Sci Rep,7(7206),2045-2322.
MLA Zheng X, He J, Wang L, Zhou S, Peng X, Huang S, Zheng L, Cheng L, Hao Y, Li J, Xu J, Xu X, Zhou,et al."Ecological Effect of Arginine on Oral Microbiota".Sci Rep 7.7206(4295):2045-2322.
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