Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals

doi:10.1016/j.talanta.2017.01.015

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	Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals
	Yu, H; Wu, YN; Hu, Y; Gao, XD; Liang, Q; Xu, J; Shao, SJ; Shao, SJ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China.; Shao, SJ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.
刊名	TALANTA
	2017-04-01
卷号	165 页码:625-631
关键词	Dual-functional probe Hypochlorous acid SO2 derivatives Fluorescence imaging
ISSN号	0039-9140
DOI	10.1016/j.talanta.2017.01.015
文献子类	Article
英文摘要	In view of the important roles of reactive oxygen species (ROS) and reactive sulfur species (RSS) in the complex signal transduction and oxidation pathways, fluorescent probes that are able to display distinct signals to hypochlorous acid and SO2 derivatives are highly valuable. Herein, a novel dual-functional probe (DFP) as an efficient single fluorescent-molecule which can respond to HCIO and HSO3- with two different sets of fluorescence signals was presented. The DFP displayed desired properties such as high specificity, suitable sensitivity, appreciable water solubility and stability. The sensing mechanism was confirmed by high-resolution mass spectroscopy analysis and H-1 NMR spectrometry analysis. Moreover, as a biocompatible molecule, the DFP has been successfully applied for the detection of HCIO in living cells with a dual-channel mode. Therefore, the present work established a novel strategy for monitoring the multiple ROS and RSS species using a single fluorescent probe and the DFP is promising as a molecular tool to investigate the production and dynamics of HCIO and HSO3- in the complex interaction networks of the living system.
学科主题	Chemistry
出版地	AMSTERDAM
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [21572239, 21505145, 21275150] ; Personnel Training Project of the West Light Foundation of the Chinese Academy of Sciences ; top priority program of "One-Three-Five" Strategic Planning of Lanzhou Institute of Chemical Physics, CAS
语种	英语
WOS记录号	WOS:000394064700089
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188634]
专题	第一临床医学院_期刊论文
通讯作者	Xu, J; Shao, SJ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China.; Shao, SJ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Yu, H,Wu, YN,Hu, Y,et al. Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals[J]. TALANTA,2017,165:625-631.
APA	Yu, H.,Wu, YN.,Hu, Y.,Gao, XD.,Liang, Q.,...&Shao, SJ .(2017).Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals.TALANTA,165,625-631.
MLA	Yu, H,et al."Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals".TALANTA 165(2017):625-631.